半岛bd体育手机客户端 说明
一般描述
A cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in culturesin vitro(IC50= 5.6 and 3.7 ?M in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 ?M) and in micein vivo. Shown to cross blood-brain barrier in micein vivo. Also available in InSolution
A cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in culturesin vitro(IC50= 5.6 and 3.7 ?M in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 ?M) and in micein vivo. Shown to cross blood-brain barrier in micein vivo.
包装
10 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
STAT3 pathway
Target IC50: 5.6 and 3.7 ?M in inhibiting malignant glioma growth in a viability assay using U87-MG and U373-MG, respectively
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Iwamaru, A., et al. 2007.Oncogene,26,2435.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H14BrN3O |
| 分子量 | 356.22 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 10 mg/mL ethanol: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
