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位置: 首页> 品牌> Sigma-Aldrich> Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem

品牌
Sigma-Aldrich
CAS
4238-41-9
货号
616382
规格纯度
Inhibits trypsin-like serine proteinases.
价格
1560.15 *本价格含增值税费
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半岛bd体育手机客户端 名称:
4238-41-9
N α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem
TLCK
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Inhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50= 80 ?M). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 ?M.
Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50= 80 ?M). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.

包装

50, 250 mg in Plastic ampoule

生化/生理作用

EC50 = 80 ?M blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
trypsin like proteases

警告

Toxicity: Irritant (B)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Griscavage, J.M., et al. 1995.Biochem. Biophys. Res. Commun.215,721.
Kim, H., et al. 1995.J. Immunol.154,4741.
Bourinbaiar, A.S. and Nagorny, R. 1994.Cell Immunol.155,230.
Biro, A., et al. 1992.Eur. J. Immunol.22,2547.
Bruno, S., et al. 1992.Leukemia6,1113.
Lee, S.F. 1992.Infect. Immun.60,4032.
Schmidt, H.H., et al. 1992.Mol. Pharmacol.41,615.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H21ClN2O3S · xHCl
分子量 332.85 (free base basis)

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (elemental analysis)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 off-white
溶解性 aqueous solution, pH <6.0: 1 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI key YFCUZWYIPBUQBD-ZOWNYOTGSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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