半岛bd体育手机客户端 说明
一般描述
A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki= 13.9 nM) and MMP-9 (Ki= 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (Ki= 206 ?M) MMP-3 (Ki= 15 ?M), or MMP-7 (Ki= 96 ?M).
A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki= 13.9 nM), and MMP-9 (Ki= 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.
包装
500 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
其他说明
Krüger, A., et al. 2005.Cancer Res.65,3523.
Kleinfeld, O., et al. 2001.J. Biol. Chem.276,17125.
Brown, S., et al. 2000.J. Am. Chem. Soc.122, 6799.
法律信息
Sold under license of U.S. Patent 6,703,415.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H14O3S2 |
| 分子量 | 306.40 |
| MDL编号 | MFCD09836266 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| 效能 | 13.9 nM Ki |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
