半岛bd体育手机客户端 说明
一般描述
A cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC50= 4.7 ?M) relative to COX-1 (IC50= 36.6 ?M). Also inhibits the growth of colorectal cancer cellsin vitro.
A cell-permeable, non-steroidal, anti-inflammatory drug (NSAID) of the oxicam family that preferentially inhibits the inducible isoform of cyclooxygenase-2 (COX-2; IC50= 4.7 ?M) relative to cyclooxygenase-1 (COX-1; IC50= 36.6 ?M). Also inhibits the growth of colorectal cancer cellsin vitro.
包装
100 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 4.7 ?M, 36.6 ?M against the inducible isoform of COX-2 relative to COX-1, respectively
Primary Target
COX-2
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
其他说明
Blanco, F.J., et al. 1999.J. Rheumatol.26,1366.
Davies, N.M., and Skjodt, N.M. 1999.Clin. Pharmacokinet.36,115.
Goldman, A.P., et al. 1998.Carcinogenesis19,2195.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C14H13N3O4S2 |
| 分子量 | 351.40 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,19H,1-2H3,(H,15,16)/b13-11+ |
| InChI key | DWMREKMVXIFPFM-ACCUITESSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
