半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50= 7 nM for PKCαand PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). G? 6983 does not effectively inhibit PKC?(IC50= 20 ?M) and can thus be used to differentiate PKC?from other PKC isozymes.
A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50= 7 nM for PKCαand PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). G? 6983 does not effectively inhibit PKC?(IC50= 20 ?M) and can thus be used to differentiate PKC?from other PKC isozymes.
包装
500 μg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
PKCα and PKCβ
Product competes with ATP.
Reversible: yes
Target IC50: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
警告
Toxicity: Standard Handling (A)
其他说明
Wang, D., et al. 1998.J. Biol. Chem.273,33027.
Stempka, L., et al. 1997.J. Biol. Chem.272,6805.
Gschwendt, M., et al. 1996.FEBS Lett.392,77.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C26H26N4O3 |
| 分子量 | 442.51 |
| MDL编号 | MFCD04040031 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | orange-red |
| 溶解性 | DMSO: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
