半岛bd体育手机客户端 说明
一般描述
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
外形
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
重悬
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.
基本信息
NACRES | NA.32 |
半岛bd体育手机客户端 性质
生物来源 | human |
重组 | expressed in HEK 293 cells |
标签 | 6-His tagged (C-terminus) |
测定 | ≥90% (SDS-PAGE) |
形式 | lyophilized |
分子量 | calculated mol wt 26.1 kDa observed mol wt 45-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 29 is the predicted N-terminal.) |
包装 | pkg of 10 μg pkg of 50 μg |
UniProt登记号 | Q7Z7D3 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... VTCN1(79679) |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich