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Vitamin D receptor (118-427), His tagged human

品牌
Sigma-Aldrich
货号
SRP2074
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE)
价格
6089.88 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Vitamin D receptor (118-427), His tagged human
NR1I1
vitamin D (1,25- dihydroxyvitamin D3) receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

The vitamin D endocrine system is critical for the proper development and maintenance of mineral ion homeostasis and skeletal integrity. Beyond these classical roles, recent evidence suggests that the bioactive metabolite of vitamin D, 1,25-dihydroxyvitamin D3, functions in diverse physiological processes, such as hair follicle cycling, blood pressure regulation, and mammary gland development. The biological effects of 1,25-(OH)2D3 are mediated through the vitamin D receptor (VDR), a member of the nuclear receptor superfamily of ligand-activated transcription factors. The cellular effects of VDR signaling include growth arrest, differentiation and/or induction of apoptosis. VDR heterodimerizes with RXR and the liganded VDR-RXR heterodimer binds with high affinity to vitamin D response elements (VDREs) in the promoters of target genes. In addition, several nuclear receptor coactivators (SRC-1, DRIP) have been shown to interact with VDR and potentiate its transcriptional activity. In addition to treating disorders of mineral metabolism and diseases of the skeleton, such as rickets, osteoporosis, and renal osteodystrophy, VDR and 1,25-(OH)2D3 have significant therapeutic potential for pathologies such as cancer, autoimmune syndromes, and psoriasis.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 frozen liquid
分子量 ~37 kDa
包装 pkg of 10 μg
储存条件 avoid repeated freeze/thaw cycles
浓度 550 μg/mL
technique(s) deacetylase assay: suitable
颜色 clear colorless
NCBI登记号 NM_000376
UniProt登记号 P11473
运输 dry ice
储存温度 ?70℃
Gene Information human ... VDR(7421)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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