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VEGFR2/Flk-1/KDR human

品牌
Sigma-Aldrich
货号
SRP6406
规格纯度
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
价格
3599.48 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
VEGFR2/Flk-1/KDR human
kinase insert domain receptor
CD309
VEGFR
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Kinase insert domain receptor (KDR) also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi′s sarcoma lesions.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in HEK 293 cells
标签 6-His tagged (C-terminus)
测定 ≥95% (SDS-PAGE)
形式 lyophilized
分子量 calculated mol wt 84.1 kDa
observed mol wt 100-110 kDa by SDS-PAGE (DTT-reduced. Protein migrates due to glycosylation.)
包装 pkg of 100 μg
pkg of 20 μg
杂质 <1 EU/μg endotoxin (LAL test)
UniProt登记号 P35968
运输 wet ice
储存温度 ?20℃
Gene Information human ... VEGFR2(3791)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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