您好,欢迎来到半岛电竞官方网址 ! [登录] [免费注册]
半岛电竞官方网址
位置:首页 > 品牌 > Sigma-Aldrich > Vatalanib dihydrochloride

Vatalanib dihydrochloride

品牌
Sigma-Aldrich
CAS
212141-51-0
货号
SML2498
规格纯度
≥98% (HPLC)
价格
610.65 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
半岛bd体育手机客户端 名称:
212141-51-0
Vatalanib dihydrochloride
1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine dihydrochloride
CGP 79787D dihydrochloride
N-(4-Chloroanilino)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
ZK-222584 dihydrochloride
PTK 787 dihydrochloride
ZK222584 dihydrochloride
PTK787 dihydrochloride
ZK 222584 dihydrochloride
CGP 79787 dihydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Vatalanib (PTK787, ZK 222584, CGP 79787D, CGP 79787 succinate) is an orally active anilinophthalazine derivative that exerts its anti-angiogenic efficacy by targeting receptor tyrosine kinase (RTK) VEGFR (VEGFR1/2 IC50 = 54/39 nM; IC50 ∼30 nM against 100 ng/mL VEGF-C-induced VEGFR3 autophosphorylation in MEVCs) and, to a less extent, PDGFRβ, c-kit, c-fms (IC50 = 364, 600, 567 nM, respectively) in an ATP-competitive manner with much reduced or no potency toward >90 other kinases. Typical dosing ranges: 0.1-10 μM in cultures, 5 nM-200 μM (zebrafish) and 30-100 mg/kg (mice & rats via po. or ip) in vivo.

基本信息

经验(实验)分子式C20H15ClN4 · 2HCl
分子量419.73
MDL编号MFCD08458963

半岛bd体育手机客户端 性质

测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性H2O: 2 mg/mL, clear
储存温度2-8℃
SMILES stringClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map