半岛bd体育手机客户端 说明

一般描述

Unc-51 like autophagy activating kinase 1 (ULK1) is a serine/threonine protein kinase which forms a component of the ULK1 protein kinase complex. This protein complex also contains the adaptor proteins ATG (autophagy-related) 13, RB1CC1/FIP200 (RB1-inducible coiled-coil 1), and ATG101. The gene encoding this protein is localized on human chromosome 12q24.33.

应用

GST-ULK1 has been used inin vitrokinase assay.

生化/生理作用

Unc-51 like autophagy activating kinase 1 (ULK1) protein kinase plays a crucial role in the control of autophagy initiation. This protein is responsible for activating a cascade of signaling pathways which results in the formation of phagosomes. ULK1 is also required for the control of the expression of key interferon-stimulated genes (ISGs).

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

重组	expressed in baculovirus infectedSf9 cells
半岛bd体育手机客户端 线	PRECISIO?Kinase
测定	≥70% (SDS-PAGE)
形式	buffered aqueous glycerol solution
specific activity	46-62 nmol/min·mg
分子量	~125 kDa
NCBI登记号	BC111603
运输	dry ice
储存温度	?70℃
Gene Information	human ... ULK1(8408)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable