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ULK Active human

品牌
Sigma-Aldrich
货号
SRP0252
规格纯度
recombinant, expressed in FreeStyleTM293-F cells, ≥40% (SDS-PAGE)
价格
8831.52 *本价格含增值税费
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半岛bd体育手机客户端 名称:
ULK Active human
UNC-51-like kinase
ATG1 autophagy related 1 homolog
ATG1
Serine/threonine-protein kinase ULK1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

ULK1 (unc-51 like autophagy activating kinase 1) is a Ser/Thr protein kinase which forms a component of the ULK1 protein kinase complex. This protein complex also contains the adaptor proteins ATG (autophagy-related) 13, RB1CC1/FIP200 (RB1-inducible coiled-coil 1), and ATG101. ULK1 protein is one of the five orthologs of yeast Atg1 found in mammals.

生化/生理作用

ULK1 (unc-51 like autophagy activating kinase 1) protein kinase plays a crucial role in the control of autophagy initiation. This protein is responsible for activating a cascade of signaling pathways which ultimately results in the formation of phagosomes. The phosphorylation of ULK1 by MTORC1 (mammalian target of rapamycin complex) leads to the negative regulation of autophagy. Activation of type I interferon (IFN) receptor (IFNR) results in the activation of ULK1 protein, which, in turn, results in the transcription of gene in a IFN-stimulated response elements (ISRE) and IFNγ activation site (GAS) elements-mediated manner. It is also required for the control of the expression of key IFN-stimulated genes (ISGs).

外形

Formulated in 2 5mM Tris-HCl, pH 7.5, 100 mM NaCl, 0.05% Tween-20, 100 μg/ml FLAG peptide, 20% glycerol and 3 mM DTT.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

法律信息

FreeStyle is a trademark of Invitrogen Corp.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in FreeStyle?293-F cells
测定 ≥40% (SDS-PAGE)
形式 aqueous solution
分子量 113 kDa
包装 pkg of 10 μg
manufacturer/tradename Invitrogen
储存条件 avoid repeated freeze/thaw cycles
浓度 >0.02 mg/mL
NCBI登记号 NM_003565
UniProt登记号 O75385
运输 dry ice
储存温度 ?70℃
Gene Information human ... ULK1(8408)

Sigma-Aldrich

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