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Ubiquitin-K6 human

品牌
Sigma-Aldrich
货号
SRP6128
规格纯度
recombinant, expressed inE. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
价格
1827.92 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Ubiquitin-K6 human
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one of the seven lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have all available lysines mutated to arginines, except at position 6. This molecule, therefore, can only form polyubiquitin chains of K6 linkage type. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach. Ubiquitin plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.

外形

4 mg/mL in PBS.

制备说明

Centrifuge the vial prior to opening.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥95% (HPLC)
≥95% (SDS-PAGE)
形式 liquid
分子量 8.732 kDa
包装 pkg of 500 μg
NCBI登记号 P62979
运输 dry ice
储存温度 ?70℃
Gene Information human ... RPS27A(6233)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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