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Tubulin, GST tagged human

品牌
Sigma-Aldrich
CAS
1622402-26-9
货号
SRP5148
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
价格
4088.34 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
1622402-26-9
Tubulin, GST tagged human
MGC117247
M40
TUBB5
MGC16435
OK/SW-cl.56
TUBB
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tubulin-β 1 (TUBB1) protein is a major constituent of microtubules. Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both α and β tubulin monomers. It is found in hematopoietic cells and platelet marginal bands. The gene encoding TUBB1 is localized on human chromosome 6p21.

应用

GST tagged tubulin has been used in Western blotting and in mass spec as a control.

生化/生理作用

Tubulin-β 1 (TUBB1) interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. It has a role in the formation of the cytoskeleton. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance.

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 buffered aqueous glycerol solution
分子量 ~76 kDa
NCBI登记号 NM_178014
application(s) cell analysis
运输 dry ice
储存温度 ?70℃
Gene Information human ... TUBB(203068)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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