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TRKA (G595R), Active

品牌
Sigma-Aldrich
货号
SRP0718
规格纯度
PRECISIO?Kinase, recombinant
价格
5177.2 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
TRKA (G595R), Active
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Useful for kinase assay.

生化/生理作用

Recombinant human TRKA (G595R) (440-end) was expressed byBaculovirusin Sf9 insect cells using an N-terminal GST tag. TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation(1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease(2).

重悬

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

半岛bd体育手机客户端 性质

重组 expressed in baculovirus infectedSf9 cells
测定 70-95% (SDS-PAGE)
形式 frozen liquid
specific activity 2.0-3.0 nmol/min·mg
分子量 ~66 kDa
浓度 0.05 μg/μL
登记号 NM_002529
运输 dry ice
储存温度 ?70℃
Gene Information human ... TRKA(4914)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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