TNCA - 半岛电竞官方网址

半岛bd体育手机客户端名称：

42438-90-4
TNCA
(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
Lycoperodine-1

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

包装

10, 50 mg in glass bottle

生化/生理作用

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

基本信息

经验(实验)分子式	C₁₂H₁₂N₂O₂
分子量	216.24
MDL编号	MFCD00272641
PubChem化学物质编号	329826033
NACRES	NA.77

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
颜色	white to beige
溶解性	1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
储存温度	−20℃
SMILES string	O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
InChI	1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
InChI key	FSNCEEGOMTYXKY-JTQLQIEISA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable