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Tim-4 (human): FC (human)

品牌
Sigma-Aldrich
货号
SRP8057
规格纯度
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
价格
8416.19 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Tim-4 (human): FC (human)
TIMD4
T-cell membrane protein 4
TIM4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute at 100 μg/mL in sterile PBS.

其他说明

The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of human IgG1.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in CHO cells
测定 ≥98% (SDS-PAGE)
形式 lyophilized
分子量 monomer 58 kDa by calculation
包装 pkg of 100 μg
杂质 <0.06 EU/μg endotoxin, tested
颜色 white
UniProt登记号 Q96H15
运输 wet ice
储存温度 ?20℃
Gene Information human ... TIMD4(91937)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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