半岛bd体育手机客户端 说明
包装
10, 50 mg in glass bottle
生化/生理作用
SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50of 21 nM for Pim-1 compared to an IC50of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.
基本信息
| 经验(实验)分子式 | C11H6F3NO2S |
| 分子量 | 273.23 |
| MDL编号 | MFCD01152003 |
| PubChem化学物质编号 | 329825328 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: >10 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1 |
| InChI | 1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| InChI key | NGJLOFCOEOHFKQ-YVMONPNESA-N |
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