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SMAD4, GST tagged human

品牌
Sigma-Aldrich
货号
SRP5133
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
价格
4311.28 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
SMAD4, GST tagged human
DPC4
MADH4
JIP
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SMAD4 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands. TGFβ stimulation leads to phosphorylation and activation of SMAD1, SMAD2 and SMAD3, which form complexes with SMAD4 that accumulate in the nucleus and regulate transcription of target genes. SMAD signaling is negatively regulated by inhibitory SMADs and ubiquitin-mediated processes and proteasomal degradation of SMADs depend on the direct interaction of specific E3 ligases with SMADs. SMAD4 is targeted for degradation by multiple ubiquitin ligases that can simultaneously act on R-SMADs and signaling receptors. Such mechanisms of down-regulation of TGFβ signaling via degradation of SMADs may be critical for proper physiological response to this pathway.

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 buffered aqueous glycerol solution
分子量 ~95 kDa
NCBI登记号 NM_005359
application(s) cell analysis
运输 dry ice
储存温度 ?70℃
Gene Information human ... SMAD4(4089)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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