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Sirtuin 3 human

品牌
Sigma-Aldrich
货号
SRP0117
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE)
价格
8365.25 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Sirtuin 3 human
sir2-like 3
Sirt3
Mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
SIR2L3
Silent mating type information regulation 2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Sirtuin 3 (SIRT3) is a member of a family of NAD+-dependent protein deacetylases called sirtuins (SIRTs). In mammals, there are seven types of SIRTs (SIRT1 to 7). SIRT 3 is present in mitochondrial matrix.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

Sirtuin 3 (SIRT3) is thought to be involved in metabolism as its expression is suppressed in muscles of diabetic animals and increased in white and brown adipose tissues during calorie restriction (CR). This protein modulates the degree of acetylation and activity of acetyl-coenzyme A synthetase 2, an enzyme thought to be involved in energy production during starvation conditions in mammals. Up-regulation of this gene influences the expression of genes involved in mitochondrial function. During fasting, SIRT3 controls mitochondrial intermediary metabolism and fatty-acid use by deacetylating long-chain acyl coenzyme A dehydrogenase (LCAD). It is an essential modulator of basal ATP, and therefore, overall energy homeostasis.

单位定义

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37℃.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 aqueous solution
分子量 59 kDa
包装 pkg of 100 μg
储存条件 avoid repeated freeze/thaw cycles
浓度 >0.02 mg/mL
NCBI登记号 NM_012239
UniProt登记号 Q9NTG7
运输 dry ice
储存温度 ?70℃
Gene Information human ... SIRT3(23410)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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