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RXRα, ligand binding domain, (200-462), GST tagged human

品牌
Sigma-Aldrich
货号
SRP2125
规格纯度
recombinant, expressed inE. coli, ≥80% (SDS-PAGE)
价格
4949.94 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
RXRα, ligand binding domain, (200-462), GST tagged human
NR2B1
FLJ16020
FLJ16733
FLJ00280
FLJ00318
MGC102720
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Retinoid X receptor (RXR) serves as a promiscuous heterodimerization partner for many nuclear receptors through the identity box, a 40-amino acid subregion within the ligand binding domain (LBD). RXR partners include thyroid hormone receptors (TRs), retinoic acid receptors (RARs), peroxisome proliferator-activated receptor, several constitutive active orphan nuclear receptors (e.g. nuclear growth factor I-B), oxysterol receptors, and constitutive androstane receptors. RXRs also form homodimers to mediate the effects of 9-cis-retinoic acid (9-cRA). Depending on these protein-protein interactions, RXR-containing complexes have distinct ligand-dependent and constitutive functions. The LBD is functionally complex and mediates ligand binding, receptor homo- and heterodimerization, repression of transcription in the absence of ligand, and ligand-dependent activation of transcription. Hormone binding to the structurally conserved LBD of the RXR triggers a conformational change that principally affects the conserved C-terminal transactivation helix H12 involved in transcriptional activation. Coactivators directly recruited by liganded receptors include members of the steroid receptor coactivator/p160 family such as SRC-1, transcriptional intermediary factor 2/glucocorticoid receptor interacting protein 1, and RAC3/activator of thyroid and retinoic acid receptors/amplified in breast cancer 1.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥80% (SDS-PAGE)
形式 frozen liquid
分子量 ~56.5 kDa
包装 pkg of 10 μg
储存条件 avoid repeated freeze/thaw cycles
浓度 350 μg/mL
颜色 clear colorless
NCBI登记号 NM_002957
UniProt登记号 P19793
运输 dry ice
储存温度 ?70℃
Gene Information human ... RXRA(6256)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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