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Rupatadine fumarate

品牌
Sigma-Aldrich
CAS
182349-12-8
货号
SML2898
规格纯度
≥98% (HPLC)
价格
833.87 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
182349-12-8
Rupatadine fumarate
UR-12592 fumarate
8-Chloro-11-{1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene}-6,11-dihydro-5 H-benzo[5,6]cyclohepta[1,2- b]pyridine (E)-2-butenedioate (1:1)
UR12592 fumarate
5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-, (E)-2-butenedioate (1:1)
UR 12592 fumarate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Rupatadine (UR-12592) is an orally active, dual histamine H1 and platelet-activating factor (PAF) receptor antagonist (Ki(app) = 100/550 nM against pyrilamine/WEB2086 binding to guinea pig cerebellum/rabbit platelet membranes) that inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29) and PAF-induced platelet aggregation (IC50= 0.68 μM/human PRP). Rupatadine blocks histamine-/PAF-induced hypotension (ID50= 1.4/0.44 mg/kg i.v. rats) and bronchoconstriction (ID50= 113/9.6 μg/kg i.v. guinea pigs), as well as prevents mortality caused by PAF (ID50= 0.31 mg/kg i.v. or 3.0 mg/kg p.o. mice) and endotoxin (mice/rats ID50= 1.6/0.66 mg/kg i.v.)in vivo.

基本信息

经验(实验)分子式 C26H26ClN3· C4H4O4
分子量 532.03
MDL编号 MFCD00926499

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
InChI 1S/C26H26ClN3.C4H4O4/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25;5-3(6)1-2-4(7)8/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChI key JYBLCDXVHQWMSU-WLHGVMLRSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P264 - P270 - P301 + P312 - P501
危险分类 Acute Tox. 4 Oral
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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