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位置: 首页> 品牌> Sigma-Aldrich> Rabbit anti-TRF2 Antibody, Affinity Purified

Rabbit anti-TRF2 Antibody, Affinity Purified

品牌
Sigma-Aldrich
货号
PLA0144
规格纯度
Powered by Bethyl Laboratories, Inc.
价格
6227.32 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Rabbit anti-TRF2 Antibody, Affinity Purified
TRF2
TTAGGG repeat-binding factor 2
telomeric repeat binding protein 2
TRBF2
telomeric DNA-binding protein
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The telomeric repeat binding factor 2 (TRF2 ) gene codes for a component of shelterin. The encoded protein is dimer containing four domains : B domain at the N-terminal, the TRF homology domain, the hinge domain and the MYB/SANT (proto-oncogene, transcription factor telobox) domain at C-terminal.

免疫原

The epitope recognized by PLA0144 maps to a region between residue 375 and 425 of human Telomeric Repeat Binding Factor 2 using the numbering given in entry NP_005643.1 (GeneID 7014).

生化/生理作用

TRF2 (telomeric repeat binding factor 2) is responsible for telomere stability by the insertion of the 3′ overhang. TRF2 offers protection to DNA from being wrongly recognized by the DNA damage repair systems. Loss of TRF2 function induces DNA repair system resulting in apoptosis by causing cell cycle arrest. Upregulation of the TRF2 gene is observed in cancer and thus concluded to contribute to tumor progression.

外形

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

其他说明

Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity purified immunoglobulin
antibody product type primary antibodies
等级 Powered by Bethyl Laboratories, Inc.
species reactivity human
technique(s) immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000
登记号 NP_005643.1
运输 wet ice
储存温度 2-8℃
Gene Information rabbit ... TRF2(7014)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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