半岛bd体育手机客户端 说明

一般描述

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

外形

Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.

重悬

Reconstitute with 100 μL deionized water.

其他说明

Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	mouse
重组	expressed in HEK 293 cells
偶联物	untagged
测定	>95% (SDS-PAGE)
形式	lyophilized
分子量	~65 kDa by SDS-PAGE
包装	pkg of 10 μg
杂质	<0.1 EU/μg endotoxin, tested
颜色	white
UniProt登记号	P28798
运输	wet ice
储存温度	?20℃
Gene Information	mouse ... Grn(14824)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable