PRMT4 peptide, biotin

半岛bd体育手机客户端 说明

一般描述

Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.

应用

Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.

生化/生理作用

Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.

外形

Supplied in a TRIS-buffered solution.

其他说明

200 μL at 400 μM, or 80 nmol. Sold as 80 nmol

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

测定	≥90% (HPLC)
形式	aqueous solution
包装	pkg of 80 nmol
浓度	400 μM
UniProt登记号	Q86X55
运输	dry ice
储存温度	?70℃
Gene Information	human ... CARM1(10498)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable