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PPAR, α human

品牌
Sigma-Aldrich
货号
SRP2043
规格纯度
recombinant, expressed inE. coli, ≥75% (SDS-PAGE)
价格
5416.19 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
PPAR, α human
NR1C1
MGC2452
PPAR
MGC2237
PPARalpha
hPPAR
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9-cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPAR α is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPAR β is found in many tissues but the highest expression is in the gut, kidney and heart. PPAR γ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. The target genes of PPAR α are a relatively homogenous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes and mitochondria) and lipoprotein assembly and transport.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥75% (SDS-PAGE)
形式 frozen liquid
分子量 ~54 kDa
包装 pkg of 10 μg
储存条件 avoid repeated freeze/thaw cycles
浓度 250 μg/mL
technique(s) electrophoretic mobility shift assay: suitable
颜色 clear colorless
NCBI登记号 NM_005036
UniProt登记号 Q07869
运输 dry ice
储存温度 ?70℃
Gene Information human ... PPARA(5465)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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