Plasminogen Activator Substrate

半岛bd体育手机客户端 说明

Amino Acid Sequence

BOC-Val-Gly-Arg-βNA

应用

Plasminogen Activator Substrate has been used as a fluorogenic thrombin substrate to measure the fluorescence released by cleavage of the thrombin substrate to assess the functional activity of the mannose-binding lectin–mannose-associated serine protease (MBL-MASP) complex.
Plasminogen Activator is a serine protease that coverts plasminogen into plasmin. Plasminogen activator may be detected using VGR peptide substrates such a BOC-VGR-βNA and Boc-Val-Gly-Arg-AMC (VGR).

生化/生理作用

Plasminogen activator (PA) is used to cure life-threatening coronary and cerebrovascular blockages. The important role of the PA system is to convert the inactive plasminogen to plasmin. However, it also plays a vital role in embryogenesis, cell migration, wound healing, inflammatory response, and apoptotic cell death. The PA system is also involved in tumor growth, angiogenesis, tumor cell invasion, migration, and metastasis in cancer patients.

基本信息

经验(实验)分子式	C28H41N7O5
分子量	555.67
NACRES	NA.32

半岛bd体育手机客户端 性质

测定	≥95% (HPLC)
形式	lyophilized
组成	Peptide Content, ≥80%
储存条件	protect from light
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable