Phthalimidooxy-dPEG^?₄-NHS ester

半岛bd体育手机客户端 说明

特点和优势

Phthalimidooxy-dPEG^?₄-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactiveN-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^?spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^?spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

基本信息

经验(实验)分子式	C23H28N2O11
分子量	508.48
MDL编号	MFCD28155511
PubChem化学物质编号	329823874
NACRES	NA.22

半岛bd体育手机客户端 性质

测定	>90%
形式	solid or viscous liquid
reaction suitability	reagent type: cross-linking reagent reactivity: amine reactive reagent type: cross-linking reagent reactivity: thiol reactive
聚合物结构设计	shape: linear functionality: heterobifunctional
运输	ambient
储存温度	?20℃
SMILES string	O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable