帕唑帕尼 - 半岛电竞官方网址

帕唑帕尼

品牌

Sigma-Aldrich

货号

SML3104

包装型号

规格纯度

≥98% (HPLC)

价格

780.67 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Pazopanib
GW786034
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
GW 786034
帕唑帕尼

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

Pazopanib is an orally active receptor tyrosine kinases inhibitor against VEGFR1/2/3 (IC50 = 10/30/47 nM), PDGFR1/2 (IC50 = 84/71 nM) and c-Kit (IC50 = 74 nM), exhibiting reduced or no potency toward FGFR1/3 (IC50 = 140/130 nM), c-fms (IC50 = 146 nM), and other kinases tested (IC50 from >400 nM to >20 μM). Pazopanib exhibits anti-cancer efficacy in cultures (IC50 from 5 to 15 μg/mL; multiple myeloma migration and survival) and in mice in vivo (30-100 mg/kg/day p.o. against human MM xenografts) via angiogenesis inhibition and apoptosis induction.

基本信息

经验(实验)分子式	C₂₁H₂₃N₇O₂S
分子量	437.52
MDL编号	MFCD11616589

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	CN1N=C2C=C(N(C3=NC(NC4=CC=C(C(S(N)(=O)=O)=C4)C)=NC=C3)C)C=CC2=C1C
InChI	1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChI key	CUIHSIWYWATEQL-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H360FD - H373 - H411
预防措施声明	P202 - P260 - P273 - P280 - P308 + P313 - P391
危险分类	Aquatic Chronic 2 - Repr. 1B - STOT RE 2
靶器官	Liver
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable