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p53 (1-81), mutant, GST tagged human

品牌
Sigma-Aldrich
货号
SRP2108
规格纯度
recombinant, expressed inE. coli, ≥80% (SDS-PAGE)
价格
4311.28 *本价格含增值税费
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半岛bd体育手机客户端 名称:
p53 (1-81), mutant, GST tagged human
TRP53
LFS1
P53
FLJ92943
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1.

生化/生理作用

The protein has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein.
p53 was identified as a tumor suppressor by showing that this protein has the ability to block transformation and to inhibit tumor cell growth. In addition, p53 is a transcription factor capable of regulating the expression of a subset of downstream genes. Mutation of two specific N-terminal residues in p53 (residues Leu22 and Trp23) impairs the ability of p53 to transactivate and has been correlated with its ability to bind TAFII40 and TAFII60 (or TAFII31 and TAFII70) (7, 8) suggesting that one or both of these interactions is important for activation. Mutation of residues 22 and 23 to Ala does not affect binding to TBP, although mutation of these residues to charged amino acids has been reported to disrupt the p53-TBP interaction. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥80% (SDS-PAGE)
形式 frozen liquid
分子量 ~34.5 kDa
包装 pkg of 10 μg
浓度 450 μg/mL
颜色 clear colorless
NCBI登记号 NM_000546
UniProt登记号 P04637
运输 dry ice
储存温度 ?70℃
Gene Information human ... TP53(7157)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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