半岛bd体育手机客户端 说明
一般描述
MSK2 (mitogen- and stress-activated protein kinase-2) is a member of the serine/threonine kinase family that contains two non-identical kinase catalytic domains. MSK2 is also known as ribosomal protein S6 kinase polypeptide 4 (RPS6KA4), that is activated by the mitogen-activated protein kinases- extracellular signal-regulated kinases 1 and 2 (ERK1 and -2) and p38.
生化/生理作用
MSK2 (mitogen- and stress-activated protein kinase-2) phosphorylates various substrates like cyclic AMP-responsive element-binding protein 1 (CREB1) and the proto-oncogene c-fos. It is a histone-modifying enzyme and a mitogenic factor. The protein is involved in the G1-phase of the cell cycle and has a role in apoptosis. It also modulates the functions of various transcription factors.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
NACRES | NA.32 |
半岛bd体育手机客户端 性质
重组 | expressed in baculovirus infectedSf9 cells |
半岛bd体育手机客户端 线 | PRECISIO?Kinase |
测定 | ≥70% (SDS-PAGE) |
形式 | buffered aqueous glycerol solution |
specific activity | 7.5-10.4 nmol/min·mg |
分子量 | ~114 kDa |
NCBI登记号 | BC012964 |
运输 | dry ice |
储存温度 | ?70℃ |
Gene Information | mouse ... Rps6ka4(56613) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
Sigma-Aldrich