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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-PLEKHA7 antibody produced in mouse

Monoclonal Anti-PLEKHA7 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200643
规格纯度
clone PLK7, purified from hybridoma cell culture
价格
6092.23 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-PLEKHA7 antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-PLEKHA7 (mouse IgG2a isotype) is derived from the hybridoma PLK7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the N-terminal region of human PLEKHA7, conjugated to KLH. PLEKHA7 contains WW (rsp5-domain), PH (pleckstrin homology), and CC (coiled-coil) domains.
PLEKHA7 (Pleckstrin homology domain containing, family A member 7) is an adherens junction protein localized at the adherens junctions in colonic epithelial cells.

免疫原

synthetic peptide corresponding to a sequence at the N-terminal region of human PLEKHA7

应用

Monoclonal Anti-PLEKHA7 antibody has been used in

  • immunoblotting
  • immunocytochemistry
  • flow cytometry

生化/生理作用

PLEKHA7 (Pleckstrin homology domain containing, family A member 7) functions as a cytoplasmic component of the epithelial adherens junction belt, with a subcellular localization and tissue distribution and connects E-cadherin-p120 ctn complex to the microtubule cytoskeleton. It has been reported that PLEKHA7 acts as zonula adherens (ZA) component, identifies Nezha, which further binds to microtubules (MTs) of the cytoskeleton, and forms a protein complex during cytoskeleton assembly.
Overexpression of PLEKHA7 was reported to be common in invasive lobular carcinomas (ILCs) and hence PLEKHA7 could serve as a molecular marker to differentiate ILCs from invasive ductal carcinomas (IDCs).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 PLK7, monoclonal
形式 buffered aqueous solution
species reactivity human
浓度 ~1 mg/mL
technique(s) flow cytometry: 2-4 μg/test using NCI-H1299 cells
immunoblotting: suitable
immunocytochemistry: 0.25-0.5 μg/mL using human CaCo2 cells
同位素/亚型 IgG2a
UniProt登记号 Q6IQ23
运输 dry ice
储存温度 ?20℃
Gene Information human ... PLEKHA7(144100)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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