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Monoclonal Anti-PCLO antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB5200018
规格纯度
clone 6H9-B6, 1 mg/mL, purified immunoglobulin
价格
4618.16 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Monoclonal Anti-PCLO antibody produced in mouse
Anti-Aczonin
Anti-ACZ
Anti-PICO
Anti-presynaptic cytomatrix protein antibody
Anti-PCLO
Anti-Piccolo, 6H9-B6
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PCLO (presynaptic cytomatrix protein) gene codes for a protein called piccolo. The encoded protein is a component of the presynaptic active zone.

特异性

No cross-reactivity to Bassoon, band at ~550 kDa correspondng to the molecular weight of Piccolo.

免疫原

Full length protein, Accession Number BC001304.1

生化/生理作用

PCLO (presynaptic cytomatrix protein) gene might be associated with the risk of major depression disorder and bipolar disorder. Mutation in PCLO gene results in pontocerebellar hypoplasia. PCLO serves as a biomarker type 2 diabetes. It controls presynaptic monoamine production. Piccolo plays an important role in synaptic transmission. It mediates the process of docking, vesicle priming and retrieval. Piccolo is involved in neurotransmission and functions at ribbon synapses. Loss of piccolo causes synapse degeneration due to the breakdown of many presynaptic proteins. It regulates ubiquitination, F-actin assembling and proteostasis which helps in maintaining synaptic integrity.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 6H9-B6, monoclonal
形式 buffered aqueous glycerol solution
分子量 antigen predicted mol wt 550 kDa
species reactivity human, rat
浓度 1 mg/mL
technique(s) indirect ELISA: suitable
western blot: suitable
同位素/亚型 IgG2bκ
NCBI登记号 NP_001104266.1
UniProt登记号 Q9Y6V0
运输 wet ice
储存温度 ?20℃
Gene Information mouse ... Pclo(26875)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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