Monoclonal Anti-PCLO antibody produced in mouse

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一般描述

PCLO (presynaptic cytomatrix protein) gene codes for a protein called piccolo. The encoded protein is a component of the presynaptic active zone.

特异性

No cross-reactivity to Bassoon, band at ~550 kDa correspondng to the molecular weight of Piccolo.

免疫原

Full length protein, Accession Number BC001304.1

生化/生理作用

PCLO (presynaptic cytomatrix protein) gene might be associated with the risk of major depression disorder and bipolar disorder. Mutation in PCLO gene results in pontocerebellar hypoplasia. PCLO serves as a biomarker type 2 diabetes. It controls presynaptic monoamine production. Piccolo plays an important role in synaptic transmission. It mediates the process of docking, vesicle priming and retrieval. Piccolo is involved in neurotransmission and functions at ribbon synapses. Loss of piccolo causes synapse degeneration due to the breakdown of many presynaptic proteins. It regulates ubiquitination, F-actin assembling and proteostasis which helps in maintaining synaptic integrity.

特点和优势

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外形

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

免责声明

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