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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-MLL2 antibody produced in mouse

Monoclonal Anti-MLL2 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1402978
规格纯度
clone 2E1, purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-MLL2 antibody produced in mouse
Anti-AAD10
Anti-KMT2B
AAD10
Anti-KMT2D
Anti-CAGL114
Anti-Kabuki mental retardation syndrome
MLL4
Anti-Kabuki make-up syndrome
Anti-MLL4
Anti-Myeloid/lymphoid or mixed-lineage leukemia 2
ALR
Anti-TNRC21
CAGL114
Anti-ALR
Anti-Histone-lysine N-methyltransferase
Anti-ALL1-related protein
TNRC21
Anti-KMS
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Mixed-lineage leukemia 2 (MLL2), a histone methyltransferase that belongs to the trithorax group, is expressed ubiquitously in adult tissues. Structurally, MLL2 comprises plant homeodomain (PHD), Su(var)3-9, Enhancer-of-zeste and Trithorax (SET) domain, and a high mobility group (HMG) box. The MLL2 gene is mapped to human chromosome 12q13.12.

免疫原

MLL2 (NP_003473.1, 1487 a.a. ~ 1586 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SKLEGMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPE

生化/生理作用

Mixed-lineage leukemia 2 (MLL2) regulates the expression of homeobox (Hox) genes. Mutations or haploinsufficiency in the MML2 gene is implicated in Kabuki syndrome, a multi-systemic disorder. It carries out methylation on the lysine 4 of histone H3 (H3K4). MLL2 plays a tumor suppressor role in Merkel cell carcinoma.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 2E1, monoclonal
形式 buffered aqueous solution
分子量 antigen ~37.11 kDa
species reactivity human
technique(s) indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2aκ
NCBI登记号 NM_003482
运输 dry ice
储存温度 ?20℃
Gene Information human ... MLL2(8085)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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