Monoclonal Anti-KLK4, (C-terminal) antibody produced in mouse

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一般描述

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. (provided by RefSeq) Kallikrein related peptidase 4 (KLK4) is a hormone-regulated peptide expressed in prostate, testis, epidermis and other tissues. The gene encoding it is localized on human chromosome 19q13.4.

免疫原

KLK4 (NP_004908.2, 159 a.a. ~ 254 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
GRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGQDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS

生化/生理作用

Kallikrein related peptidase 4 (KLK4) has a role in male reproduction and tooth enamel maturation. It degrades proteins in the extracellular matrix. The protein has been linked to oral squamous cell carcinoma and prostate cancer. Inactivation of KLK4 is associated with a subtype of amelogenesis imperfecta (2A1).

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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