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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-HOOK3 antibody produced in mouse

Monoclonal Anti-HOOK3 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1401891
规格纯度
clone 3A5, purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-HOOK3 antibody produced in mouse
FLJ31058
hK3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM

免疫原

HOOK3 (NP_115786.1, 622 a.a. ~ 718 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
QNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR

生化/生理作用

InCaenorhabditis elegans, the HOOK3 (hook microtubule-tethering protein 3) protein is required for connecting the centrosome and the nucleus. It participates in transport of pericentriolar satellites, needed for centrosomal assembly in neurogenesis. HOOK3-RET (ret proto-oncogene) fusion protein is identified in papillary thyroid carcinoma and it results in tumor formation in nude mice. In presence ofSalmonella entericainfection, the Salmonella SpiC (pathogenicity island 2 secreted effector protein) inactivates HOOK3 function and thereby affects the cellular trafficking and phagosome-lysosome fusion.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 3A5, monoclonal
形式 buffered aqueous solution
species reactivity human
technique(s) capture ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2aκ
NCBI登记号 NM_032410
UniProt登记号 Q86VS8
运输 dry ice
储存温度 ?20℃
Gene Information human ... HOOK3(84376)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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