半岛bd体育手机客户端 说明
一般描述
Human histocompatibility leukocyte antigen–G (HLA-G) belongs to the non-classical class I HLA family. It is encoded by the gene mapped to human chromosome 6p21. Unlike other members of the human class I gene family, HLA-G is expressed specifically in extraembryonic tissues during gestation.
The antibody 5A6G7 allows to discriminate between soluble HLA-G protein yielded by shedding from membrane-bound HLA-G forms that do not contain the intron 4-encoded epitope and soluble HLA-G5/HLA-G6 produced from intron 4-retaining alternatively spliced mRNAs. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.
免疫原
C-terminal amino acid sequence (22-mer) of soluble HLA-G5 and HLA-G6 proteins coupled to ovalbumin
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Human histocompatibility leukocyte antigen-G (HLA-G) molecule facilitates the regulation of maternal tolerance to the fetus by interacting with inhibitory receptors on natural killer (NK) cells. The encoded protein is involved in the embryonic development and/or the fetal-maternal immune response. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 5A6G7, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 浓度 | 1 mg/mL |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NM_002127.5 |
| UniProt登记号 | P17693 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... HLA-G(3135) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
