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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-FTH1 antibody produced in mouse

Monoclonal Anti-FTH1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200598
规格纯度
~1.0 mg/mL, clone FTH24, purified immunoglobulin
价格
5045.46 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-FTH1 antibody produced in mouse
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Monoclonal Anti-FTH1
Monoclonal Anti-PLIF
Monoclonal Anti-ferritin heavy chain
Monoclonal Anti-ferritin, heavy polypeptide 1
Monoclonal Anti-FTHL6
Monoclonal Anti-FHC
Monoclonal Anti-PIG15
Monoclonal Anti-placenta immunoregulatory factor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-FTH1 (mouse IgG1 isotype) is derived from the hybridoma FTH24 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal sequence of human FTH1. Ferritin, a highly conserved iron-binding protein, is composed of two subunits, namely a 21 kDa heavy (H) chain and a 19 kDa light (L) chain. Ferritin heavy chain 1 gene is mapped on human chromosome 11q13. It is mainly found in heart and pancreas.

特异性

Monoclonal Anti- FTH1 recognizes human FTH1.

免疫原

synthetic peptide corresponding to an internal sequence of human FTH1. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

应用

Monoclonal Anti-FTH1 antibody produced in mouse may be used in:

  • immunoblotting
  • immunocytochemistry
  • flow cytometry
  • immunofluorescence

生化/生理作用

Ferritin heavy chain catalyzes the first step in iron storage, the oxidation of Fe(II) to Fe(III). In addition to iron buffering, heavy chain ferritin also enhancesde novothymidine biosynthesis. Serum ferritin level is the most commonly used marker for determining iron status stored in the body. It is markedly influenced by factors such as inflammation, malnutrition, malignancy, and iron overload disorders. Studies have found that defects in ferritin proteins are also associated with several neurodegenerative diseases. FTH1 can also be used as a possible prognostic marker for breast cancer.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For extended storage, freeze at -20 ℃ in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 FTH24, monoclonal
形式 buffered aqueous solution
species reactivity human
浓度 ~1.0 mg/mL
technique(s) flow cytometry: 10-20 μg/test using HeLa cells
immunoblotting: 0.5-1.0 μg/mL using total cell extracts of HEK-293T cells overexpressing FTH1 (expected: ~26kDa).
indirect immunofluorescence: 5-10 μg/mL using HeLa cells
同位素/亚型 IgG1
UniProt登记号 P02794
运输 dry ice
储存温度 ?20℃
Gene Information human ... FTH1(2495)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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