Monoclonal Anti-FOXP3 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4⁺CD25⁺regulatory T-cell subsets.

免疫原

Purified recombinant fragment of human Foxp3 expressed inE.coli.
Mouse monoclonal antibody raised against Foxp3

应用

Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).

生化/生理作用

Forkhead box P3 (FOXP3) plays an essential role in the development of CD4⁺CD25⁺regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).

外形

Ascitic fluid containing 0.03% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	unconjugated
抗体形式	ascites fluid
antibody product type	primary antibodies
克隆	2A11G9, monoclonal
species reactivity	mouse, human
technique(s)	direct ELISA: 1:10,000 immunohistochemistry: 1:200-1:1,000 indirect immunofluorescence: 1:200-1:1,000 western blot: 1:500-1:2,000
同位素/亚型	IgG1
NCBI登记号	NM_014009
UniProt登记号	Q9BZS1
运输	wet ice
储存温度	?20℃
Gene Information	human ... Foxp3(50943)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable