Monoclonal Anti-EndoG antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

ENDOG (Endonuclease G) is a 28kDa mitochondria-localized protein mapped to human chromosome 9q34.1. However, in presence of certain conditions it can translocate to the nucleus through the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway.

免疫原

Mouse monoclonal EndoG antibody was raised against a recombinant protein corresponding to amino acids 51 – 140 of human EndoG.

应用

Monoclonal Anti-EndoG antibody produced in mouse is suitable for indirect ELISA and western blot.

生化/生理作用

ENDOG (Endonuclease G) is a mitochondrial apoptotic DNase involved in the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway. During mitochondrial release and nuclear translocation of EndoG, BNIP3 interacts with the voltage-dependent anion channel (VDAC) to facilitate the process in the nucleus, it cleaves chromatin apoptotic DNA without the need of caspase activity. ENDOG causes DNA fragmentation during and after apoptosis. It is linked to cardiac hypertrophy and Parkinson′s disease.

特点和优势

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外形

Supplied in PBS with 0.02% sodium azide.

基本信息

MDL编号

MFCD04040310

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	7F2D7, monoclonal
形式	buffered aqueous solution
species reactivity	rat, mouse, human
technique(s)	indirect ELISA: suitable western blot: suitable
NCBI登记号	Q14249
UniProt登记号	Q14249
运输	dry ice
储存温度	?20℃
Gene Information	human ... ENDOG(2021)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable