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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-EndoG antibody produced in mouse

Monoclonal Anti-EndoG antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB3500469
规格纯度
clone 7G1G10, purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-EndoG antibody produced in mouse
Anti-Endonuclease G
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

ENDOG (Endonuclease G) is a 28kDa mitochondria-localized protein mapped to human chromosome 9q34.1. However, in presence of certain conditions it can translocate to the nucleus through the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway.

免疫原

Mouse monoclonal EndoG antibody was raised against a recombinant protein corresponding to amino acids 51 – 140 of human EndoG.

应用

Monoclonal Anti-EndoG antibody produced in mouse is suitable for indirect ELISA and western blot.

生化/生理作用

ENDOG (Endonuclease G) is a mitochondrial apoptotic DNase involved in the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway. During mitochondrial release and nuclear translocation of EndoG, BNIP3 interacts with the voltage-dependent anion channel (VDAC) to facilitate the process in the nucleus, it cleaves chromatin apoptotic DNA without the need of caspase activity. ENDOG causes DNA fragmentation during and after apoptosis. It is linked to cardiac hypertrophy and Parkinson′s disease.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied in PBS with 0.02% sodium azide.

基本信息

MDL编号 MFCD04040310
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 7G1G10, monoclonal
形式 buffered aqueous solution
species reactivity rat, human
technique(s) indirect ELISA: suitable
western blot: suitable
NCBI登记号 Q14249
UniProt登记号 Q14249
运输 dry ice
储存温度 ?20℃
Gene Information human ... ENDOG(2021)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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