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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-C10orf54 antibody produced in mouse

Monoclonal Anti-C10orf54 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200644
规格纯度
clone ORF.4, purified from hybridoma cell culture
价格
6567.14 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-C10orf54 antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-C10orf54 (mouse IgG1 isotype) is derived from the hybridoma OR.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide.C10orf54 (Chromosome 10 open reading frame 54) is also referred to as GI24, B7 member B7-H5, VISTA (V-domain Ig suppressor of T cell activation) and Dies1. It is a novel surface glycoprotein belonging to the B7 immunoglobulin superfamily. It consists of a single IgV domain with 3 additional cysteine residues and a cytoplasmic tail. It is expressed on mature myeloid APCs (antigen-presenting cells) including peritoneal macrophages, mature BMDC (bone marrow-derived dendritic cell), neutrophils and CD11c+DCs, and to a lesser quantity in T cells and activated Treg cells.

免疫原

synthetic peptide corresponding to a sequence at the internal region of human C10orf54

应用

Phosphotyrosine antibody inhibitor has been used in flow-cytometry and immunohistochemistry.

生化/生理作用

Studies suggest that C10orf54 (Chromosome 10 open reading frame 54) functions as a co-inhibitory ligand and restricts the mechanism of T cell proliferation and cytokine production. It was also suggested that C10orf 54 acts as a positive regulator as well as a substrate of MT1-MMP (trans-membrane type 1-matrix metalloproteinase) during tumor growth of collagen matrix, which regulates invasive growth.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 ORF.4, monoclonal
形式 buffered aqueous solution
species reactivity human
浓度 ~1 mg/mL
technique(s) flow cytometry: 10 μg/test using human platelets
immunohistochemistry: suitable
同位素/亚型 IgG1
运输 dry ice
储存温度 ?20℃
Gene Information human ... C10orf54(64115)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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