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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-CD33-Biotin antibody produced in mouse

Monoclonal Anti-CD33-Biotin antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700154
规格纯度
clone HIM3-4, purified immunoglobulin, buffered aqueous solution
价格
4053.29 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-CD33-Biotin antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Myeloid cell surface antigen CD33, (cluster of differentiation 33) also known as SIGLEC3, siglecs (sialic acid binding Ig-like lectins) and GP67, belongs to the CD33-related SIGLEC gene family. It is a type 1 transmembrane protein and contains two immunoglobulin-like extracellular domains, a single transmembrane area and two intracellular inhibitory motifs. The CD33 gene is mapped to human chromosome 19q13.41.
The antibody HIM3-4 reacts with CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells; it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

免疫原

NFMY-9s human cell line

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1:1000. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Association of CD33 (cluster of differentiation 33) with sialic acid-containing ligands causes suppression of proinflammatory pathways in monocytes and macrophages. It is mainly involved in anti-inflammatory signaling, cell adhesion and endocytosis functions. CD33 also works as a myeloid differentiation marker. Mutations in the CD33 gene are associated with Alzheimer′s disease susceptibility and acute myeloid leukemia treatment efficacy. In microglia, increase in the expression of CD33 decreases amyloid β peptide

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 biotin conjugate
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 HIM3-4, monoclonal
形式 buffered aqueous solution
species reactivity human, nonhuman primates
浓度 1 mg/mL
technique(s) flow cytometry: suitable
同位素/亚型 IgG1
NCBI登记号 NM_001082618.1
UniProt登记号 P20138
运输 wet ice
储存温度 2-8℃
Gene Information human ... CD33(945)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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