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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-CD20-Biotin antibody produced in mouse

Monoclonal Anti-CD20-Biotin antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700116
规格纯度
clone 2H7, purified immunoglobulin, buffered aqueous solution
价格
4053.29 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-CD20-Biotin antibody produced in mouse
Anti-MS4A1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intesity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR amd CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.

特异性

The antibody 2H7 reacts with CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

免疫原

Human tonsillar B cells

应用

The reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 biotin conjugate
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 2H7, monoclonal
形式 buffered aqueous solution
species reactivity human, nonhuman primates
浓度 1 mg/mL
technique(s) flow cytometry: suitable
同位素/亚型 IgG2a
NCBI登记号 NM_021950.3
UniProt登记号 P11836
运输 wet ice
储存温度 2-8℃
Gene Information human ... MS4A1(931)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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