Monoclonal Anti-CD16 azide free antibody produced in mouse

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一般描述

CD16 also known as Fc fragment of IgG receptor IIIa (FCGR3A) gene is localized to human chromosome 1 and codes for FCγIIIa receptor (FcγRIIIa). The encoded protein is expressed on natural killer (NK) cells and macrophages. CD16 is a transmembrane protein characterized with a 21 amino acid cytoplasmic tail.

免疫原

Human granulocytes

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 5-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Fc fragment of IgG receptor IIIa (FCGR3A), also known as FCγ IIIa receptor (FcγRIIIa) or CD16A, is one of the activating Fc receptors to which, the Fc region of Immunoglobulin G (IgG) binds and mediates inflammatory responses such as antibody-dependent cell-mediated cytotoxicity (ADCC). Dimorphism in CD16, might influence the therapeutic response to rituximab, which is an anti-CD20 humanized immunoglobulin G1 extensively used in the treatment of non-Hodgkin lymphomas. Mutation in the gene might lead to natural killer (NK) cell immunodeficiency.

特点和优势

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外形

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

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安全信息