半岛bd体育手机客户端 说明
一般描述
The antibody MEM-05 reacts with CD31 (PECAM-1), a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
The cluster of differentiation 31 (CD31), also known as platelet and endothelial cell adhesion molecule 1 (PECAM1) gene, spanning 75kb, is mapped on the long arm of human chromosome 17. This gene codes for 130kDa protein, which belongs to the immunoglobulin (Ig) superfamily. It is a vital component of the endothelial cell intercellular junction. CD31 is expressed on the surface of circulating platelets, monocytes, neutrophils and selected T-cell subsets.
免疫原
Leukocytes of patient suffering from LGL-type leukaemia
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Cluster of differentiation 31 (CD31) plays a crucial role in the adhesion cascade leading to leukocyte extravasation during the inflammatory process. The encoded protein is essential for leukocyte transmigration via intercellular junctions of vascular endothelial cells. Genetic polymorphism of the gene is associated with atherosclerotic events. CD31, is a membrane glycoprotein that facilitates both homophilic and heterophilic adhesion. CD31 is also implicated in angiogenesis.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | MEM-05, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 浓度 | 1 mg/mL |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NM_000442.4 |
| UniProt登记号 | P16284 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... PECAM1(5175) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
