半岛bd体育手机客户端 说明
一般描述
CD19 (cluster of differentiation 19) is a 95kDa protein localized on the surface of nearly all B lymphocytes and is considered to be the specific surface marker for B cells.This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ～240 amino acids and is involved in the regulation of B cell function.The protein is encoded by the 7.41kb cd19 gene, mapped on the short arm of human chromosome 16p11.2. There are certain localized regions of strong net negative charges with nine tyrosine residues in the cytoplasmic region of CD19. These regions might regulate the interaction of CD19 with the proto-oncogene Vav, phosphatidylinositol-3 kinase (PI-3 kinase) and the Lyn, Lck and Fyn protein tyrosine kinases.
免疫原
Human CCL (chronic lymphocytic leukemia) cells
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
CD19 (cluster of differentiation 19) expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen.The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 4G7, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NM_001178098.1 |
| UniProt登记号 | P15391 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... CD19(930) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
