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Monoclonal Anti-CD28 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700751
规格纯度
clone CD28.2, purified immunoglobulin, buffered aqueous solution
价格
3548.32 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-CD28 antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cluster of differentiation 28 (CD 28) is a lymphocyte surface protein. In human chromosome, the gene CD28 is localized on 2q33.2. The antibody CD28.2 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. HLDA V.; WS Code 5T CD28.05.

免疫原

DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA

生化/生理作用

Cluster of differentiation 28 (CD28) acts as a costimulatory molecule for T cell activation and proliferation. CD28 might function as a tumor suppressor gene and the polymorphism is related to increased risk of breast cancer. CD28 plays a key role in allogenic responses. The level of CD28 is upregulated in CD4+ lymphocytes during acute graft rejection. Polymorphism in CD28 owing to higher frequency of CD28 molecule has impact on schizophrenia. Mutations in CD28 is associated with T cell lymphoma′s and neoplasm, leading to accelerated tumour growth. CD28 along with phosphatidylinositol 3 kinase (PI3K) regulates diverse biochemical pathways. CD28 signals to T cells and prevents anergy and apoptosis and promotes T cell proliferation and production of interleukin-2.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 CD28.2, monoclonal
形式 buffered aqueous solution
species reactivity human, nonhuman primates
浓度 1 mg/mL
technique(s) FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG1
NCBI登记号 NM_001243077.1
UniProt登记号 P10747
运输 wet ice
储存温度 2-8℃
Gene Information human ... CD28(940)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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