Monoclonal Anti-CD71 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.
Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.

免疫原

NALM-6 human pre-B cell line

应用

Monoclonal Anti-CD71 antibody produced in mouse has been used in co-immunoprecipitation assay.
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.

特点和优势

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外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	MEM-75, monoclonal
形式	buffered aqueous solution
species reactivity	human
浓度	1 mg/mL
technique(s)	flow cytometry: suitable
同位素/亚型	IgG1
NCBI登记号	NM_001128148.1
UniProt登记号	P02786
运输	wet ice
储存温度	2-8℃
Gene Information	human ... TFRC(7037)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable