Monoclonal Anti-Biglycan antibody from mouse

半岛bd体育手机客户端 说明

一般描述

Biglycan (BGN) is class I small leucine rich proteoglycans (SLRP), encoded by the gene mapped to human chromosome Xq28. The encoded protein is characterized with two chondroitin sulfate glycosaminoglycan (GAG) chains attached near its NH₂terminus. Biglycan is expressed as a constituent of extracellular matrices in various tissues.
Monoclonal Anti-Biglycan (mouse IgG1 isotype) is derived from the hybridoma 905A7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.

特异性

Monoclonal Anti-Biglycan recognizes human and bovine biglycan.

应用

Monoclonal Anti-Biglycan antibody from mouse may be used in:

• immunoblotting
• immunohistochemistry
• enzyme-linked immunosorbent assay (ELISA)

生化/生理作用

In vitrostudies state that biglycan (BGN) plays a vital role in the connective tissue metabolism by interacting with collagen fibrils-4 and transforming growth factor (TGF)-β and might also enhance neuronal survival. It also plays a crucial role in maintaining the structural integrity of the aortic wall. Variation in the gene expression leads to X-linked, severe, syndromic form of thoracic aortic aneurysm and dissection (TAAD), including hypertelorism, pectus deformity, joint hypermobility, contractures, and mild skeletal dysplasia. In addition, mutation in the gene is associated with the development of Happle syndrome.
Biglycan signaling provides an important link between innate and adaptive immunity. This protein also plays a crucial role in the regulation of inflammation, bone growth, and muscle development and regeneration. Biglycan is involved in various human diseases, such as asthma, atherosclerosis, cancer, diabetes, and kidney disease.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For extended storage, freezeat -20 ℃in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify thesolution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	905A7, monoclonal
species reactivity	bovine, human
浓度	1 mg/mL
technique(s)	immunohistochemistry: 5-10 μg/test using using human kidney tissue sections.
同位素/亚型	IgG1
UniProt登记号	P21810
储存温度	?20℃
Gene Information	bovine ... BGN(280733)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable