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Monoclonal Anti-APOE antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB5300354
规格纯度
clone 1H4, ascites fluid
价格
5045.46 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-APOE antibody produced in mouse
LDLCQ5
LPG
AD2
MGC1571
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Apolipoprotein E (ApoE) belongs to a group of proteins that bind reversibly with lipoproteins. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers have significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. The gene encoding this protein is localized on human chromosome 19q13.32.

免疫原

Purified recombinant fragment of human ApoE expressed inE.coli.
Mouse monoclonal antibody raised against ApoE

生化/生理作用

In addition to facilitating solubilization of lipids, apolipoproteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Apolipoprotein E (ApoE) plays an important role in lipid metabolism. It′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (Apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III.

外形

Ascitic fluid containing 0.03% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 ascites fluid
antibody product type primary antibodies
克隆 1H4, monoclonal
分子量 36 kDa
species reactivity human
technique(s) direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000
同位素/亚型 IgG1
NCBI登记号 NM_000041.2
UniProt登记号 P02649
运输 wet ice
储存温度 ?20℃
Gene Information human ... ApoE(348)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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